| Malaria |
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MORU's Malaria research team, led by Arjen Dondorp (Department Head and Deputy Director of the MORU) and Kesinee Chotivanich (Head of Laboratory Malaria), conducts treatment studies in severe and uncomplicated malaria, investigates the ever increasing problem of antimalarial drug resistance, and uses innovative tools to investigate the complicated pathophysiology of malaria. MORU’s Malaria department works closely with the Department of Clinical Tropical Medicine (Faculty of Tropical Medicine, Mahidol University), where many of our collaborators are based including Prof Sasithon Pukrittayakamee and Dr Malika Imwong. Many studies involve collaborations with MORU’s Pharmacology department and mathematical modelling team. Malaria studies are also conducted by SMRU and the Laos Unit. The malaria clinical study sites are in Mae Sot in Thailand (vivax and uncomplicated falciparum malaria), Pailin in Western Cambodia (artemisinin resistance studies), Chittagong in Bangladesh and Rourkela in India (both severe malaria studies) and in eight African countries where the large AQUAMAT trial is currently being executed. Human malaria infection is caused by four species of mosquito-borne parasites of the genus Plasmodium. Malaria remains a massive health problem worldwide, infecting more than 400 million people annually, of which approximately one million will die from the disease. |
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