Objectives

uncomplicated-severe-malaria
Antimalarial drug exposure after currently recommended doses and after a revised dosing regimen in children with uncomplicated and severe malaria

The overall long term objective is to identify sub-groups of patients at increased risk of infectious disease treatment failures or adverse drug reactions such as pregnant women and young children, and optimise the treatments for these vulnerable populations. The departments work has evolved naturally from accurate and sensitive bioanalytical drug measurements to pharmacometric modelling and evidence-based dose-optimisation. We aim to expand these important themes with biochemistry and drug discovery research to better understand the disease pathophysiology and mechanism of action and to develop new targets to integrate in quantitative measurements and pharmacometric modelling. Building local research capacity is a key strategic aim and we currently have 5 students studying for their PhDs with us.