Pharmacology Research
Our main scientific directions within the department are;
1. Bioanalytical method development using various sample preparation techniques (such as solid-phase extraction, liquid-liquid extraction) in combination with LC-MS, LC-MS/MS and LC-UV/DAD for quantification of antimalarial, anti-tuberculosis and anti-retroviral drugs. Development of new assays are focused to become low volume and field adapted (i.e. finger prick sampling) to facilitate pharmacokinetic studies in vulnerable populations.
2. Development of quality systems including improvement of validation procedures, improve and influence international guidelines, establish inter-laboratory quality schemes.
3. Pharmacokinetic data analysis including non-compartmental modeling, compartmental modeling on the individual and the population basis. Study the interactions between antimalarial, antituberculosis, and antiretroviral drugs.
4. Research on pharmacogenetics and other aspects of drug metabolism including metabolite identification, identification of metabolic pathways.
