AQUAMAT - African Quinine v. Artesunate Malaria Trial

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The results of the AQUAMAT study were announced at the American Society of Tropical Medicine and Hygiene (ASTMH) Conference in Atlanta on 6th November 2010, with the full paper available for download from the Lancet website from 8th November (see links below). This landmark study conducted in 11 study sites in nine African countries, enrolled 5,425 children with severe malaria. The results demonstrate that compared with quinine, artesunate reduced the mortality rate from 10.9% to 8.5%, a relative reduction of 22.5%. This finding is consistent with the findings of the earlier SEAQUAMAT study conducted in Asia, which showed a 35% reduction in mortality. Please see the links below for the press release and for the AQUAMAT and SEAQUAMAT manuscripts.

AQUAMAT abstract

SEAQUAMAT abstract